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Home Antibody All anti-GCK antibodies

Anti-GCK Antibody

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SKU Description Amount Price Availability*  
TA321073 Anti-GCK Rabbit Polyclonal Antibody 100ul $325 In Stock
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IHC(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 3-17 amino acids of Human glucokinase (hexokinase 4)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.4mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:1000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target Nameglucokinase
Alternative NameFGQTL3|GK|GLK|HHF3|HK4|HKIV|HXKP|LGLK|MODY2
Database LinkNP_000153
Entrez Gene 2645 Human
Entrez Gene 103988 Mouse
Entrez Gene 24385 Rat
FunctionHexokinases phosphorylate glucose to produce glucose-6-phosphate; the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase; one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase; this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM); maturity onset diabetes of the young; type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Related PathwayDruggable Genome Glycolysis / GluconeogenesisGalactose metabolismStarch and sucrose metabolismAmino sugar and nucleotide sugar metabolismMetabolic pathwaysInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


IHC Image
Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using GCK antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200)
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