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Home Antibody All anti-GCK antibodies

Anti-GCK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321073
  • Anti-GCK Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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IHC(1)
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Also for GCK (NM_000162)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 3-17 amino acids of Human glucokinase (hexokinase 4)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.4mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:1000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens glucokinase (hexokinase 4) (GCK), transcript variant 1
Alternative NameFGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
Database LinkNP_000153
FunctionHexokinases phosphorylate glucose to produce glucose-6-phosphate; the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase; one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase; this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM); maturity onset diabetes of the young; type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Related Pathway
MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using GCK antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200)

 

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