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Home Antibody All anti-E2F4 antibodies

Anti-E2F4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321027
  • Goat Polyclonal Anti-E2F4 Antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

Immunogeninternal region of NP_001941.2 (DPTGVLELPKELSE)
Clone Name Isotype
Species ReactivityHuman Concentration0.5mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1-3µg/ml
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Reference Data

Target NameHomo sapiens E2F transcription factor 4, p107/p130-binding (E2F4)
Alternative NameE2F-4
Database LinkNP_001941
FunctionThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008].
Related Pathway
Adipogenesis
Cell cycle
TGF Beta Signaling Pathway

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WB Image
E2F4 antibody (2µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer) . Primary incubation was 1 hour. Detected by chemiluminescence.

 

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