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Anti-TSC22D3 Antibody CFMKG15
Also for TSC22D3 (NM_010286)
||0.5-1mg/ml (lot dependent)
||Flow, ICC, WB
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Affinity purified (Protein A or G Sepharose)
|Mus musculus TSC22 domain family, member 3 (Tsc22d3), transcript variant 2|
|DIP; Dsip1; Gilz; Tilz3; TSC-22R|
|GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-κB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-κB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining.|
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Left: Immunoblot of mouse thymocytes cultured without (lane 1) or with (lane 2) dexamethasone (10e-7 M) for 3 hr. The membrane was probed with 10 ug/mL of Anti-Human/Mouse GILZ Purified, followed by Anti-Rat IgG HRP. Right: Immunoblot of normal human peripheral blood cells cultured without (lane 1) or with (lane 2) dexamethasone (10e-7 M) for 3 hr. The membrane was probed with 2 ug/mL of Anti-Human/Mouse GILZ Purified, followed by Anti-Rat IgG HRP.