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Anti-SELE Antibody P2H3
Also for SELE (NM_000450)
||Flow, IHC, Functional Assay, IP
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Homo sapiens selectin E (SELE)|
|CD62E; ELAM; ELAM1; ESEL; LECAM2|
Entrez Gene 6401 Human
|The P2H3 monoclonal antibody reacts with human CD62E, a 97-115 kDa member of the selectin family. CD62E, also known as E-selectin or endothelial-leukocyte adhesion molecule-1 (ELAM-1) is an adhesion molecule expressed by endothelial cells upon stimulation with cytokines including TNFα and IL-1β. Induced expression of CD62E during inflammatory conditions is thought to mediate leukocyte rolling including the initial interaction of neutrophils with endothelium.The P2H3 monoclonal antibody also inhibits cellular adhesion to cytokine-activated endothelial cells.|
|TransmembraneDruggable Genome Cell adhesion molecules (CAMs)|
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Staining of TNF alpha-stimulated Human Umbilical Vein Endothelial Cells (HUVEC) with 0.5 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD62E (E- Selectin) Purified (filled histogram) followed by F(ab')2 Anti-Mouse IgG PE . Total viable cells were used for analysis.