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Home Antibody All anti-FAS antibodies

Anti-FAS Antibody EOS9.1

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA320327 Mouse Anti-Human CD95 (APO-1/Fas) Purified (25 ug) 25ug $120 3-7 Days
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FC(1)

OriGene Data

Immunogen
Clone NameEOS9.1 Isotype
Species ReactivityHuman Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *FC Suggested DilutionsFlow, Functional Assay
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameHomo sapiens Fas cell surface death receptor (FAS), transcript variant 1
Alternative NameALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Database LinkNP_000034
Entrez Gene 355 Human
FunctionThe EOS9.1 monoclonal antibody reacts with human CD95 (Fas, Apo-1), a 40-50 kDa member of the TNFR superfamily. CD95 is expressed by a broad range of hematopoietic and non-hematopoietic cells including monocytes, neutrophils, activated lymphocytes and fibroblasts. Interaction of CD95 on mature lymphocytes with its ligand (FasL) induces apoptosis and is thought to be important in peripheral tolerance. EOS9.1 does not block binding of DX2, another antibody specific for human CD95.
Related PathwaySecreted ProteinES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionp53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicityType I diabetes mellitusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

The Jurkat cell line was treated for 6 hours with medium alone (left) or 0.1 ug/mL of Anti-Human CD95 (APO-1/Fas) Functional Grade Purified (right). Induction of apoptosis in these cells was determined by staining with Propidium Iodide and Anti-BrdU-FITC using the Apo-BrdU Apoptosis Detection Kit .
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