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Anti-CD86 Antibody 24F
Also for CD86 (NM_020081)
||0.5-1mg/ml (lot dependent)
||Flow, IHC, Functional Assay, IP
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Rattus norvegicus CD86 molecule (Cd86)|
|The 24F monoclonal antibody reacts with rat CD86, an ~90 kDa surface receptor, also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed by germinal center B cells and at low levels on macrophages, dendritic cells and non-lymphoid cells in the thymus. Its expression is upregulated on B cells through a variety of surface stimuli including LPS. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.|
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Surface staining of LPS-stimulated rat splenocytes with Anti-Rat CD86 (B7-2) FITC (left) and PE (right). Autofluorescence is shown via open histogram. Total viable cells were used for analysis.