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Anti-CD3E Antibody eBioG4.18 (G4.18)
Also for CD3E (NM_001108140)
||0.5-1mg/ml (lot dependent)
||Flow, IHC, IP, WB
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Rattus norvegicus CD3 molecule, epsilon (Cd3e)|
|The eBioG4.18 monoclonal antibody recognizes the rat CD3 protein. CD3 is a critical component of the T-cell receptor (TCR) and is a marker of the T-cell lineage. CD3 is a complex of several subunits and, upon binding of a TCR ligand, participates in transduction of signals from the TCR to the nucleus which results in a variety of cellular responses including transcription of IL-2 and clonal expansion. in vitro, immobilized G4.18 monoclonal antibody has been demonstrated to activate T cells, while soluble G4.18 inhibited allogeneic mixed-lymphocyte proliferative responses and cell-mediated cytotoxicity to allogeneic target cells. in vivo, G4.18 was demonstrated to induce long-term specific tolerance to an organ allograft.|
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Staining of rat splenocytes with 0.25 ug of Mouse IgG3 Isotype Control Purified (open histogram) or 0.25 ug of Anti-Rat CD3 Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE . Cells in the lymphocyte gate were used for analysis.