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Home Antibody All anti-GEMC1 antibodies

Anti-GEMC1 Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA320198 Rabbit Polyclonal GEMC1 Antibody 100ug $325 3-7 Days
LC431294 GMNC HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenGEMC1 antibody was raised against a 19 amino acid synthetic peptide near the center of human GEMC1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/mL
BufferGEMC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification GEMC1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens geminin coiled-coil domain containing (GMNC)
Alternative NameGEMC1
Database LinkNP_001140158
Entrez Gene 647309 Human
Entrez Gene 239789 Mouse
FunctionGEMC1 Antibody: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide


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