Home Antibody All anti-NLRP4 antibodies
Anti-NLRP4 Antibody Polyclonal
Also for NLRP4 (NM_134444)
|NALP4 antibody was raised against a 13 amino acid synthetic peptide near the center of human NALP4.|
||ELISA, WB: 1 ug/ml
|NALP4 Antibody is supplied in PBS containing 0.02% sodium azide.|
|NALP4 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens NLR family, pyrin domain containing 4 (NLRP4)|
|CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2|
Entrez Gene 147945 Human
|NALP4 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-κB induction by TNF-α and IL-1β, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-κB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-κB activity.|
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Western blot analysis of NALP4 in K562 cell lysate with NALP4 antibody at 1 ug/mL.