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Anti-PRICKLE1 Antibody Polyclonal
Also for PRICKLE1 (NM_153026)
|PRICKLE1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IF: 20 ug/ml
|PRICKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|PRICKLE1 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 1|
|PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.|
Wnt Signaling Pathway
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Western blot analysis of PRICKLE1 in human bladder tissue lysate with PRICKLE1 antibody at 1 ug/mL.
Immunofluorescence of PRICKLE1 in human bladder cells with PRICKLE1 antibody at 20 ug/mL.