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Anti-ORAI3 Antibody 1B4F1

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320076
  • Mouse ORAI3 Monoclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403460) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3.
Clone Name1B4F1 IsotypeIgG2b
Species ReactivityHuman, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 2 ug/ml
BufferORAI3 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 3 (ORAI3)
Alternative NameTMEM142C
Database LinkNP_689501
Entrez Gene 93129 Human
Entrez Gene 309000 Rat
FunctionORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ORAI3 in rat lung tissue lysate with ORAI3 antibody at 2 ug/mL.

 

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