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Anti-IL33 Antibody 12B3C4
Also for IL33 (NM_001199640)
|Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein.|
|WB, IHC, IF
||WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|IL-33 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|IL-33 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens interleukin 33 (IL33), transcript variant 2|
|C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV|
Entrez Gene 90865 Human
Entrez Gene 77125 Mouse
|IL-33 Monoclonal Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1αβ, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.|
|Secreted Protein Cytosolic DNA-sensing pathway|
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Western blot analysis of IL-33 using 125ng of recombinant IL-33 with IL-33 antibody at 1 ug/mL.
Immunohistochemistry of IL-33 in human lymph node tissue with IL-33 antibody at 5 ug/mL.
Immunofluorescence of IL-33 in human lymph node tissue with IL-33 antibody at 20 ug/mL.