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Anti-ORAI1 Antibody 6D11A11
Also for ORAI1 (NM_032790)
|Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|ORAI1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)|
|CRACM1; IMD9; ORAT1; TAM2; TMEM142A|
Entrez Gene 84876 Human
Entrez Gene 109305 Mouse
Entrez Gene 304496 Rat
|ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.|
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Western blot analysis of ORAI1 in human spleen tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL.