Home Antibody All anti-AKT1S1 antibodies
Anti-AKT1S1 Antibody Polyclonal
Also for AKT1S1 (NM_001098632)
|AKT1S1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AKT1S1.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml
|AKT1S1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|AKT1S1 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens AKT1 substrate 1 (proline-rich) (AKT1S1), transcript variant 2|
|AKT1S1 Antibody: The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia (1). AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy (2). Treatment with the insulin-like growth factor-1 (IGF1) can indusce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells (3).|
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Western blot analysis of AKT1S1 in human brain tissue lysate with AKT1S1 antibody at (A) 1 and (B) 2 ug/mL.