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Anti-KREMEN1 Antibody Polyclonal
Also for KREMEN1 (NM_001039570)
|Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||ELISA, WB: 0.5 - 1 ug/ml, IHC, IF
|KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|KREMEN1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens kringle containing transmembrane protein 1 (KREMEN1), transcript variant 3|
|KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.|
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Western blot analysis of KREMEN1 in rat small intestine tissue lysate with KREMEN1 antibody at (A) 0.125 and (B) 0.25 ug/mL