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Home Antibody All anti-CXXC4 antibodies

Anti-CXXC4 Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA320030 Rabbit Polyclonal CXXC4 Antibody 100ug $325 In Stock
LC410836 CXXC4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for CXXC4 (NM_025212)
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OriGene Data

ImmunogenCXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
BufferCXXC4 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification CXXC4 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameCXXC finger protein 4
Alternative NameIDAX
Database LinkNP_079488
Entrez Gene 80319 Human
Entrez Gene 319478 Mouse
Entrez Gene 83824 Rat
FunctionCXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
Related PathwayDruggable Genome Wnt signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

IHC Image
Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 ug/mL.

IF Image
Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 ug/mL.


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