Home Antibody All anti-KREMEN2 antibodies
Anti-KREMEN2 Antibody Polyclonal
Also for KREMEN2 (NM_145348)
|KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 ug/ml, ICC
|KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|KREMEN2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens kringle containing transmembrane protein 2 (KREMEN2), transcript variant 3|
|KRM2, MGC10791, MGC16709;KRM2; MGC10791; MGC16709; kringle-containing transmembrane protein 2; kringle containing transmembrane protein 2|
|KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.|
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Western blot analysis of KREMEN2 in HeLa cell lysate with KREMEN2 antibody at (A) 1 and (B) 2 ug/mL.