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Home Antibody All anti-KREMEN2 antibodies

Anti-KREMEN2 Antibody Polyclonal


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SKU Description Amount Price Availability*  
TA320011 Rabbit Polyclonal KREMEN2 Antibody 100ug $325 In Stock
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OriGene Data

ImmunogenKREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/mL
Predicted MW Explanation Predicted: 51 kDa Observed: 54 kDa
BufferKREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification KREMEN2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens kringle containing transmembrane protein 2 (KREMEN2), transcript variant 3
Alternative NameKRM2, MGC10791, MGC16709;KRM2; MGC10791; MGC16709; kringle-containing transmembrane protein 2; kringle containing transmembrane protein 2
Database LinkNP_663323
Entrez Gene 79412 Human
Entrez Gene 73016 Mouse
FunctionKREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
Related PathwayTransmembraneDruggable Genome

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of KREMEN2 in HeLa cell lysate with KREMEN2 antibody at (A) 1 and (B) 2 ug/mL.

IF Image
Immunocytochemistry of KREMEN2 in HeLa cells with KREMEN2 antibody at 5 ug/mL.


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