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Anti-ZBTB4 Antibody Polyclonal
Also for ZBTB4 (NM_020899)
|ZBTB4 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZBTB4.|
||ELISA, WB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|ZBTB4 Antibody is supplied in PBS containing 0.02% sodium azide.|
|ZBTB4 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens zinc finger and BTB domain containing 4 (ZBTB4), transcript variant 1|
|ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.|
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Western blot analysis of ZBTB4 in SK-N-SH cell lysate with ZBTB4 antibody at 1 ug/mL.
Immunohistochemistry of ZBTB4 in human brain tissue with ZBTB4 antibody at 2.5 ug/mL.