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Home Antibody All anti-BIRC6 antibodies

Anti-BIRC6 Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319974 Rabbit Polyclonal BRUCE Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenBRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *IHC Suggested DilutionsIHC: 5 ug/mL
Predicted MW Explanation 534 kDa
BufferBRUCE Antibody is supplied in PBS containing 0.02% sodium azide.
Purification BRUCE Antibody is affinity chromatography purified via peptide column.

Reference Data

Target Namebaculoviral IAP repeat containing 6
Alternative NameAPOLLON|BRUCE
Database LinkNP_057336
Entrez Gene 57448 Human
FunctionBRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
Related PathwayDruggable Genome Ubiquitin mediated proteolysis

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IHC Image
Immunohistochemistry of BRUCE in human small intestine tissue with BRUCE antibody at 5 ug/mL.


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