Home Antibody All anti-PIAS4 antibodies
Anti-PIAS4 Antibody Polyclonal
Also for PIAS4 (NM_015897)
|PIAS4 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human PIAS4.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PIAS4 Antibody is supplied in PBS containing 0.02% sodium azide.|
|PIAS4 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens protein inhibitor of activated STAT, 4 (PIAS4)|
|PIAS-gamma; Piasg; PIASY; ZMIZ6|
Entrez Gene 51588 Human
Entrez Gene 59004 Mouse
Entrez Gene 362827 Rat
|PIAS4 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS4. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS4 interacts with p53 and blocks its ability to induce Bax and p21 transcription. PIAS4 is also important in the control of the ubiquitin-dependent proteasomal degradation of the Ets-1 transcription factor. PIAS4 has been implicated in the DNA-damage response pathway and is thought to work in combination with PIAS1 for the productive association of 53BP1, BRCA1 and RNF168.|
|Transcription Factors Ubiquitin mediated proteolysisJak-STAT signaling pathwayPathways in cancerSmall cell lung cancer|
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Western blot analysis of PIAS4 in rat brain tissue lysate with PIAS4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of PIAS4 in rat brain tissue with PIAS4 antibody at 5 ug/mL.