Home Antibody All anti-ANAPC4 antibodies
Anti-ANAPC4 Antibody Polyclonal
Also for ANAPC4 (NM_013367)
|APC4 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human APC4.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|APC4 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC4 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens anaphase promoting complex subunit 4 (ANAPC4), transcript variant 2|
Entrez Gene 29945 Human
Entrez Gene 52206 Mouse
Entrez Gene 305420 Rat
|APC4 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC4 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC4, it is thought that APC4 associates with other APC/C components APC1, APC5, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.|
|Druggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC4 in mouse liver tissue lysate with APC4 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of APC4 in rat liver tissue with APC4 antibody at 5 ug/mL.