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Home Antibody All anti-ANAPC4 antibodies

Anti-ANAPC4 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319904
  • Rabbit Polyclonal APC4 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenAPC4 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human APC4.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
BufferAPC4 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification APC4 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens anaphase promoting complex subunit 4 (ANAPC4), transcript variant 2
Alternative NameAPC4
Database LinkNP_037499
Entrez Gene 29945 Human
Entrez Gene 52206 Mouse
Entrez Gene 305420 Rat
FunctionAPC4 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC4 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC4, it is thought that APC4 associates with other APC/C components APC1, APC5, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.
Related PathwayDruggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of APC4 in mouse liver tissue lysate with APC4 antibody at (A) 1 and (B) 2 ug/mL.
IHC Image
Immunohistochemistry of APC4 in rat liver tissue with APC4 antibody at 5 ug/mL.

 

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