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Home Antibody All anti-GLS2 antibodies

Anti-GLS2 Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319893 Rabbit Polyclonal GLS2 Antibody 100ug $325 In Stock
LC415701 GLS2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenGLS2 antibody was raised against a 18 amino acid synthetic peptide near the center terminus of human GLS2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 0.5 - 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferGLS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification GLS2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens glutaminase 2 (liver, mitochondrial) (GLS2), transcript variant 1
Alternative NameGA; GLS; hLGA; LGA
Database LinkNP_037399
Entrez Gene 27165 Human
Entrez Gene 216456 Mouse
Entrez Gene 192268 Rat
FunctionGLS2 Antibody: Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism.
Related Pathway Alanine, aspartate and glutamate metabolismArginine and proline metabolismD-Glutamine and D-glutamate metabolismNitrogen metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of GLS2 in rat kidney tissue lysate with GLS2 antibody at (A) 0.5 and (B) 1 ug/mL.
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Immunohistochemistry of GLS2 in human kidney tissue with GLS2 antibody at 5 ug/mL.
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