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Home Antibody All anti-BBC3 antibodies

Anti-BBC3 Antibody 2A9G5

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SKU Description Amount Price Availability*  
TA319890
  • Mouse PUMA Monoclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402330) , 20ug Explanation
100ug $325 3-7 Days
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WB(1)
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Also for BBC3 (NM_001127240)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Clone Name2A9G5 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 2.5 - 5 ug/ml
BufferPUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens BCL2 binding component 3 (BBC3), transcript variant 1
Alternative NameJFY-1; JFY1; PUMA
Database LinkNP_001120712
Entrez Gene 27113 Human
Entrez Gene 170770 Mouse
Entrez Gene 317673 Rat
FunctionPUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Related PathwayDruggable Genome p53 signaling pathwayHuntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/mL.
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