Home Antibody All anti-ANAPC13 antibodies
Anti-ANAPC13 Antibody Polyclonal
Also for ANAPC13 (NM_015391)
|APC13 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC13.|
|Human, Mouse, Rat
||WB: 1 ug/ml, IF: 20 ug/ml
|APC13 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC13 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens anaphase promoting complex subunit 13 (ANAPC13), transcript variant 1|
Entrez Gene 25847 Human
Entrez Gene 69010 Mouse
Entrez Gene 685029 Rat
|APC13 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC13 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC13 promotes the stable association of APC3/Cdc27 and APC6/Cdc16 with the APC/C.|
| Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC13 in Jurkat cell tissue lysate with APC13 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of APC13 in Jurkat cells with APC13 antibody at 20 ug/mL.