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Anti-LY96 Antibody 9F1B1
Also for LY96 (NM_001195797)
|Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2|
|WB, IHC, IF
||WB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|MD-2 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens lymphocyte antigen 96 (LY96), transcript variant 2|
|ESOP-1; ly-96; MD-2; MD2|
|MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.|
Toll-like receptor signaling pathway
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Western blot analysis of (A) 25 and (B) 125 ng of MD-2 recombinant protein with MD-2 antibody at 1 ug/mL.
Immunohistochemistry of MD-2 in human spleen with MD-2 antibody at 2.5 ug/mL.
Immunofluorescence of MD2 in human spleen tissue with MD2 antibody at 20 ug/mL.