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Anti-RAPGEF3 Antibody Polyclonal
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Also for RAPGEF3 (NM_001098531)
|EPAC1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EPAC1.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
|EPAC1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|EPAC1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 1|
|bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275|
Entrez Gene 10411 Human
Entrez Gene 223864 Mouse
Entrez Gene 59326 Rat
|EPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.|
| Leukocyte transendothelial migrationLong-term potentiation|
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Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 antibody at 1 ug/mL.
Immunohistochemistry of EPAC1 in rat brain tissue with EPAC1 antibody at 2.5 ug/mL.
Immunofluorescence of EPAC1 in rat brain tissue with EPAC1 antibody at 20 ug/mL.