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Home Antibody All anti-RAPGEF3 antibodies

Anti-RAPGEF3 Antibody Polyclonal


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SKU Description Amount Price Availability*  
  • Rabbit Polyclonal EPAC1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401841) , 20ug Explanation
100ug $325 3-7 Days
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Also for RAPGEF3 (NM_001098531)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody

OriGene Data

ImmunogenEPAC1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EPAC1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferEPAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification EPAC1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 1
Alternative Namebcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Database LinkNP_001092001
Entrez Gene 10411 Human
Entrez Gene 223864 Mouse
Entrez Gene 59326 Rat
FunctionEPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Related Pathway Leukocyte transendothelial migrationLong-term potentiation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 antibody at 1 ug/mL.
IHC Image
Immunohistochemistry of EPAC1 in rat brain tissue with EPAC1 antibody at 2.5 ug/mL.
IF Image
Immunofluorescence of EPAC1 in rat brain tissue with EPAC1 antibody at 20 ug/mL.


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