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Home Antibody All anti-RAPGEF3 antibodies

Anti-RAPGEF3 Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319816 Rabbit Polyclonal EPAC1 Antibody 100ug $325 3-7 Days
LC401841 RAPGEF3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for RAPGEF3 (NM_001098531)
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OriGene Data

ImmunogenEPAC1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EPAC1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferEPAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification EPAC1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens Rap guanine nucleotide exchange factor 3 (RAPGEF3), transcript variant 1
Alternative Namebcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Database LinkNP_001092001
Entrez Gene 10411 Human
Entrez Gene 223864 Mouse
Entrez Gene 59326 Rat
FunctionEPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Related Pathway Leukocyte transendothelial migrationLong-term potentiation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 antibody at 1 ug/mL.

IHC Image
Immunohistochemistry of EPAC1 in rat brain tissue with EPAC1 antibody at 2.5 ug/mL.

IF Image
Immunofluorescence of EPAC1 in rat brain tissue with EPAC1 antibody at 20 ug/mL.


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