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Home Antibody All anti-RAPGEF3 antibodies

Anti-RAPGEF3 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319816
  • Rabbit Polyclonal EPAC1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401841) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for RAPGEF3 (NM_001098531)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenEPAC1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EPAC1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferEPAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification EPAC1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 1
Alternative Namebcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Database LinkNP_001092001
FunctionEPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Related Pathway
Hemostasis

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WB Image
Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 antibody at 1 ug/mL.
IHC Image
Immunohistochemistry of EPAC1 in rat brain tissue with EPAC1 antibody at 2.5 ug/mL.
IF Image
Immunofluorescence of EPAC1 in rat brain tissue with EPAC1 antibody at 20 ug/mL.

 

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