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Home Antibody All anti-APC2 antibodies

Anti-APC2 Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319810 Rabbit Polyclonal APC2 Antibody 100ug $325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenAPC2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
BufferAPC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification APC2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens adenomatosis polyposis coli 2 (APC2)
Alternative NameAPCL
Database LinkNP_005874
Entrez Gene 10297 Human
Entrez Gene 23805 Mouse
FunctionAPC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
Related PathwayDruggable Genome Wnt signaling pathwayRegulation of actin cytoskeletonPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2 ug/mL.
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Immunofluorescence of APC2 in HeLa cells with APC2 antibody at 20 ug/mL.
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