Home Antibody All anti-APC2 antibodies
Anti-APC2 Antibody Polyclonal
Also for APC2 (NM_005883)
|APC2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC2.|
||WB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|APC2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens adenomatosis polyposis coli 2 (APC2)|
Entrez Gene 10297 Human
Entrez Gene 23805 Mouse
|APC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.|
|Druggable Genome Wnt signaling pathwayRegulation of actin cytoskeletonPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinomaMore Pathways >> |
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Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of APC2 in HeLa cells with APC2 antibody at 20 ug/mL.