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Home Antibody All anti-APC2 antibodies

Anti-APC2 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319810
  • Rabbit Polyclonal APC2 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenAPC2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
BufferAPC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification APC2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens adenomatosis polyposis coli 2 (APC2)
Alternative NameAPCL
Database LinkNP_005874
FunctionAPC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
Related Pathway
Wnt Signaling Pathway

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WB Image
Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of APC2 in HeLa cells with APC2 antibody at 20 ug/mL.

 

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