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Home Antibody All anti-KEAP1 antibodies

Anti-KEAP1 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319790
  • Rabbit Polyclonal KEAP1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC404250) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for KEAP1 (NM_012289)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenKEAP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, IF: 20 ug/ml
Predicted MW Explanation 69 kDa
BufferKEAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification KEAP1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2
Alternative NameINrf2; KLHL19
Database LinkNP_036421
Entrez Gene 9817 Human
Entrez Gene 50868 Mouse
Entrez Gene 117519 Rat
FunctionKEAP1 Antibody: KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-κB activity by targeting IKKβ degradation. Mutation of the KEAP1 gene is found in lung cancer.
Related PathwayTranscription Factors Ubiquitin mediated proteolysis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of KEAP1 in human lung tissue lysate with KEAP1 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of KEAP1 in human lung tissue with KEAP1 antibody at 20 ug/mL.

 

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