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Anti-TMEM59 Antibody Polyclonal
Also for TMEM59 (NM_004872)
|TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59.|
||ELISA, WB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TMEM59 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens transmembrane protein 59 (TMEM59)|
|TMEM59 Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.|
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Western blot analysis of TMEM59 in human kidney tissue lysate with TMEM59 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of TMEM59 in human kidney tissue with TMEM59 antibody at 2.5 ug/mL.