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Anti-KL Antibody Polyclonal
|KLOTHO antibody was raised against a 16 amino acid synthetic peptide near the center of human KLOTHO.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|KLOTHO Antibody is supplied in PBS containing 0.02% sodium azide.|
|KLOTHO Antibody is affinity chromatography purified via peptide column.
|Homo sapiens klotho (KL)|
Entrez Gene 9365 Human
Entrez Gene 16591 Mouse
Entrez Gene 83504 Rat
|KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor. |
|Secreted ProteinTransmembrane |
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Western blot analysis of KLOTHO in rat heart tissue lysate with KLOTHO antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of KLOTHO in mouse heart tissue with KLOTHO antibody at 2.5 ug/mL.
Immunofluorescence of KLOTHO in mouse heart tissue with KLOTHO antibody at 20 ug/mL.