Home Antibody All anti-CDC23 antibodies
Anti-CDC23 Antibody Polyclonal
Also for CDC23 (NM_004661)
|APC8 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC8.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml
|APC8 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC8 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens cell division cycle 23 (CDC23)|
|ANAPC8; APC8; CUT23|
Entrez Gene 8697 Human
Entrez Gene 52563 Mouse
Entrez Gene 291689 Rat
|APC8 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.|
|Druggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC8 in K562 cell lysate with APC8 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of APC8 in K562 cells with APC8 antibody at 5 ug/mL.