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Home Antibody All anti-DYRK2 antibodies

Anti-DYRK2 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319749
  • Rabbit Polyclonal DYRK2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418571) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenDYRK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DYRK2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferDYRK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification DYRK2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2), transcript variant 1
Alternative NameFLJ21217; FLJ21365
Database LinkNP_003574
Entrez Gene 8445 Human
FunctionDYRK2 Antibody: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DYRK2 in 293 cell lysate with DYRK2 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of DYRK2 in 293 cells with DYRK2 antibody at 20 ug/mL.

 

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