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Home Antibody All anti-AXIN2 antibodies

Anti-AXIN2 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319745
  • Rabbit Polyclonal AXIN2 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401475) , 20ug
100ug $325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenAXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferAXIN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification AXIN2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens axin 2 (AXIN2)
Alternative NameAXIL; ODCRCS
Database LinkNP_004646
FunctionAXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Related Pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot analysis of AXIN2 in mouse lung lysate with AXIN2 antibody at 1 ug/mL.
IHC Image
Immunohistochemistry of AXIN2 in rat lung tissue with AXIN2 antibody at 5 ug/mL.

 

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