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Anti-TNFSF4 Antibody Polyclonal
Also for TNFSF4 (NM_003326)
|Rabbit polyclonal TNFSF4 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TNFSF4.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 1 ug/ml, IHC, IF
|TNFSF4 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TNFSF4 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4), transcript variant 1|
|CD134L; CD252; GP34; OX-40L; OX4OL; TXGP1|
|TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.|
Cytokine-cytokine receptor interaction
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Western blot analysis of TNFSF4 in rat spleen tissue lysate with TNFSF4 antibody at (A) 0.5 and (B) 1 ug/mL