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Home Antibody All anti-PDCD1 antibodies

Anti-PDCD1 Antibody 12A7D7


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319693 Mouse PD-1 Monoclonal Antibody 100ug $325 3-7 Days
LC401555 PDCD1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for PDCD1 (NM_005018)
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OriGene Data

ImmunogenA ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.
Clone Name12A7D7 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/mL, ICC: 2.5 ug/mL
BufferPD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target Nameprogrammed cell death 1
Alternative NameCD279|PD-1|PD1|SLEB2|hPD-1|hPD-l|hSLE1
Database LinkNP_005009
Entrez Gene 5133 Human
Entrez Gene 18566 Mouse
Entrez Gene 301626 Rat
FunctionPD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Related PathwayTransmembraneDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PD-1 in A-20 cell lysate with PD-1 antibody at 1 ug/mL.

IHC Image
Immunohistochemistry of PD-1 in mouse brain tissue with PD-1 antibody at 2.5 ug/mL.


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