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Anti-MYD88 Antibody 2E9C2
Also for MYD88 (NM_001172566)
|Mouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.|
||WB: 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|MyD88 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|MyD88 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens myeloid differentiation primary response 88 (MYD88), transcript variant 5|
Entrez Gene 4615 Human
Entrez Gene 17874 Mouse
|MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.|
|Druggable Genome ApoptosisToll-like receptor signaling pathway|
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Western blot analysis of MyD88 in EL4 whole cell lysate with MyD88 antibody at 2 ug/mL.
Immunohistochemistry of MyD88 in human heart with MyD88 antibody at 2.5 ug/mL.