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Home Antibody All anti-MYD88 antibodies

Anti-MYD88 Antibody 2E9C2

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319687
  • Mouse MyD88 Monoclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400877) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenMouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
Clone Name2E9C2 IsotypeIgG2b
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferMyD88 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification MyD88 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens myeloid differentiation primary response 88 (MYD88), transcript variant 5
Alternative NameMYD88D
Database LinkNP_001166037
Entrez Gene 4615 Human
Entrez Gene 17874 Mouse
FunctionMyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MyD88 in EL4 whole cell lysate with MyD88 antibody at 2 ug/mL.
IHC Image
Immunohistochemistry of MyD88 in human heart with MyD88 antibody at 2.5 ug/mL.

 

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