Home Antibody All anti-IRAK1 antibodies
Also for IRAK1 (NM_001025242)
|Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.|
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|IRAK Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|IRAK Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 2|
Entrez Gene 3654 Human
Entrez Gene 16179 Mouse
|IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).|
Toll-like receptor signaling pathway
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Western blot analysis of IRAK in mouse liver lysate with IRAK antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of IRAK in rat liver tissue with IRAK antibody at 5 ug/mL.