Home Antibody All anti-FGFR3 antibodies
Anti-FGFR3 Antibody Polyclonal
Also for FGFR3 (NM_000142)
|FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml
|Predicted: 89 kDa Observed: 9+2, 98 kDa
|FGFR3 Antibody is supplied in PBS containing 0.02% sodium azide.|
|FGFR3 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1|
|ACH; CD333; CEK2; HSFGFR3EX; JTK4|
Entrez Gene 2261 Human
Entrez Gene 14184 Mouse
Entrez Gene 84489 Rat
|FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).|
|Protein KinaseTransmembraneDruggable Genome MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerBladder cancer|
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Western blot analysis of FGFR3 in SK-N-SH cell lysate with FGFR3 antibody at (A) 0.5 and (B) 1 ug/mL.