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Home Antibody All anti-ENDOG antibodies

Anti-ENDOG Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319643
  • Mouse EndoG Monoclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417987) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenRecombinant protein corresponding to amino acids 51 - 140 of human EndoG.
Clone Name IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 5 - 10 ug/ml
BufferEndoG Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification EndoG Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens endonuclease G (ENDOG)
Alternative NameFLJ27463
Database LinkNP_004426
Entrez Gene 2021 Human
Entrez Gene 13804 Mouse
Entrez Gene 362100 Rat
FunctionEndoG Monoclonal Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndoG also cleaves DNA in vitro.
Related PathwayDruggable Genome Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of EndoG expression in HepG2 cell lysate with EndoG antibody at (A) 5 and (B) 10 ug/mL.

 

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