Home Antibody All anti-ENDOG antibodies
Also for ENDOG (NM_004435)
|Recombinant protein corresponding to amino acids 51 - 140 of human EndoG.|
|Human, Mouse, Rat
||ELISA, WB: 2.5 - 5 ug/ml
|EndoG Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|EndoG Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens endonuclease G (ENDOG)|
|EndoG Monoclonal Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndoG also cleaves DNA in vitro. |
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Western blot analysis of EndoG expression in HepG2 cell lysate with EndoG antibody at (A) 2.5 and (B) 5 ug/mL.