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Home Antibody All anti-BRAF antibodies

Anti-BRAF Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319622 Chicken Polyclonal B-raf Antibody 100ug $325 3-7 Days
LC401382 BRAF HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenB-raf antibody was raised against an 18 amino acid synthetic peptide near the center of human B-raf.
Clone NamePolyclonal IsotypeIgY
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/mL
BufferB-raf Antibody is supplied in PBS containing 0.02% sodium azide.
Purification B-raf Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens B-Raf proto-oncogene, serine/threonine kinase (BRAF)
Alternative NameB-RAF1; BRAF1; NS7; RAFB1
Database LinkNP_004324
Entrez Gene 673 Human
Entrez Gene 109880 Mouse
Entrez Gene 114486 Rat
FunctionB-raf Antibody: B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. Mutations in B-raf have been associated with several cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung, leading to speculation on the possibility of B-raf as a therapeutic target for treating cancers. Mutations in this gene have also been associated with cardiofaciocutaneous syndrome (CFCS), a disease characterized by heart defects, mental retardation and a distinctive facial appearance.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwaymTOR signaling pathwayVascular smooth muscle contractionFocal adhesionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of B-raf in human brain tissue lysate with B-raf antibody at (A) 1 and (B) 2 ug/mL.


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