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Anti-APAF1 Antibody 2E10
Also for APAF1 (NM_001160)
|A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.|
|Human, Mouse, Rat
||ELISA, WB: 0.25 - 0.5 mg/ml, IHC: 0.5 ug/ml
|Apaf-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|Apaf-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 2|
Entrez Gene 317 Human
Entrez Gene 11783 Mouse
Entrez Gene 78963 Rat
|Apaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.|
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Western blot analysis of Apaf1 in K562 cell lysate with Apaf1 antibody at (A) 0.25 and (B) 0.5 mg/mL.
Immunohistochemistry of Apaf1 in K562 cells with Apaf1 antibody at 0.5 ug/mL.