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Home Antibody All anti-Esrp1 antibodies

Anti-Esrp1 Antibody 23A7.C9

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SKU Description Amount Price Availability*  
TA319605
  • Mouse monoclonal Esrp-1/2 antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenAnti-Esrp-1/2 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein.
Clone Name23A7.C9 Isotype
Species ReactivityMouse Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:750,000, WB: 1:1000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note Epithelial splicing regulatory protein-1 (Esrp-1) and Esrp-2 are mRNA splicing factors that regulate the formation of epithelial cell-specific isoforms. They specifically regulate the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 and -2 act by directly binding specific sequences in mRNAs. They bind the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Reference Data

Target NameMus musculus epithelial splicing regulatory protein 2 (Esrp2)
Alternative Name9530027K23Rik; Rbm35b
Database LinkNP_789808
Function
Related Pathway

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WB Image
Anti-Esrp-1/2 antibody by western blot shows detection in 293T cell extracts. Lane 1: GFP-transfected. Lane 2: Esrp-1 transfected (arrow). Lane 3: Esrp-2 transfected. Each lane contains approximately 5 µg of lysate. Primary antibody was used at a 1:1000 dilution in PBS-T plus milk, and reacted for 1hr at room temperature. The membrane was washed and reacted with a 1:10,000 dilution of an anti-mouse ECL antibody for 1hr at room temperature. Molecular weight estimation was made by comparison to prestained MW markers.

 

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