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Anti-PMS2 Antibody 349.29.5.2


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SKU Description Amount Price Availability*  
TA319565 Mouse monoclonal anti-PMS2 antibody 100ug $356 3-7 Days
LC424658 PMS2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenThis protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human PMS2 corresponding to the first 133 amino acid residues of the protein. The clone was produced using conventional hybridoma technology.
Clone Name349.29.5.2 Isotype
Species Reactivityhuman, mouse, rat, hamster, chimpanzee Concentration1.38 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:5,000 - 1:20,000, WB: 1:500 - 1:2,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1.  PMS is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas) and supratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). The human PMS2 gene encodes an 862 aa, 96 kDa polypeptide.

Reference Data

Target NamePMS1 homolog 2, mismatch repair system component
Alternative NameHNPCC4|MLH4|PMS2CL|PMSL2
Database LinkNP_000526
Entrez Gene 5395 Human
Entrez Gene 18861 Mouse
Entrez Gene 288479 Rat
Related PathwayDruggable Genome Mismatch repair

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
WB analysis using Monoclonal Anti-PMS2 antibody to detect human PMS2 protein present in H157 cell lysates. The blot was incubated with a 1:1,000 dilution of the antibody at RTfollowed by washing. A 1:20,000 dilution of HRP conjugated Gt-anti-Mouse IgG preceded color development using Pierce Chemical's SuperSignal™ substrate. Comparison to a molecular weight marker (not shown) indicates a single band of ~96.0 kDa corresponding to the expected molecular weight for human PMS2 protein.


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