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Home Antibody All anti-CDKN1A antibodies

Anti-CDKN1A Antibody WA-1

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319554 Mouse monoclonal p21 WAF1 antibody 100ug $356 3-7 Days
LC409213 CDKN1A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
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Also for CDKN1A (NM_000389)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenThis protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human p21 fusion protein.
Clone NameWA-1 Isotype
Species Reactivityhuman Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:5,000 - 1:20,000, WB: 1:2,000 - 1:10,000, IP: 1:100
Buffer0.02 M Potassium Phosphate, 0.5 M Sodium Chloride, pH 7.2
Note p21WAF1 is a tumor suppressor gene product critical to maintain proper regulatory control of cell division.  p21WAF1 inhibits cyclin/cyclin-dependent kinase (cdk) complexes, causing cell cycle arrest by blocking cell division at the S phase. Various mutations of tumor suppressor genes have been associated with different types of cancers.  In these cases, somatic gene therapy with wild-type versions of tumor suppressor genes have been contemplated as anti-cancer therapeutic approaches.  p21WAF1 contains p53-binding sites in its promoter and expression of p21WAF1 is induced in WI38 fibroblasts with PMA. The induction of and

Reference Data

Target NameHomo sapiens cyclin dependent kinase inhibitor 1A (CDKN1A), transcript variant 1
Alternative NameCAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
Database LinkNP_000380
Entrez Gene 1026 Human
Function
Related PathwayDruggable Genome ErbB signaling pathwayCell cyclep53 signaling pathwayPathways in cancerGliomaProstate cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Mab anti-Human p21WAF1 antibody to detect human p21 by WB. Detection occurs after 10 µg of a HeLa whole cell lysate is loaded per lane. The blot was incubated with a 1:1,000 dilution of Mab anti-Human p21WAF1at RT for 30 min followed by detection using IRDye™800 labeled Goat-a-Mouse IgG [H&L] diluted 1:5,000. The antibody may be used to detect endogenous human p21WAF1.
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