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Anti-Il1b Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319453 Rabbit polyclonal anti-IL1 beta antibody 100ug $356 2 Weeks
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OriGene Data

ImmunogenThis antibody was prepared by repeated immunizations with recombinant mouse IL-1ß produced in E.coli.  The MW of recombinant mouse IL-1ß was 17 kDa.
Clone Name IsotypeIgG
Species Reactivitymouse and rat Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsELISA: 1:1,000 - 1:5,000, WB: 1:500 - 1:2,000, IHC: 1:50-1:250, IF: 1:50-1:250, IP: 1:200-1:800, FC: User Optimized
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note IL-1 beta (also known as Interleukin-1 beta, IL-1ß and catabolin) is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1ß is a monomeric secreted protein that may be released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Anti-IL-1 beta antibody is ideal for investigators involved in Cardiovascular and Immunology research.

Reference Data

Target NameMus musculus interleukin 1 beta (Il1b)
Alternative NameIl-1b; IL-1beta
Database LinkNP_032387
Entrez Gene 16176 Mouse
Entrez Gene 24494 Rat
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
This antibody will recognize 10% of the non-denatured (native) precursor 31,000 MW mouse IL-1ß containing samples but will primarily detect all of the 17,000 MW mature molecule. However, in western blot analysis, the usual procedure of heating the sample in SDS with or without reducing agents will facilitate denaturing of the 31,000 MW IL- 1ß precursor molecule. Denatured IL-1ß will have a 18 kDa band.

IF Image
IF after staining of mouse carotid artery tissue with anti-Mouse IL-1ß antiserum (less purified form of TA319453) diluted 1:50. Panel A) shows no antibody staining of WT uninjured mouse carotid tissue. Panel B) shows anti-IL-1ß staining of cells after surgical injury of tissue. Panel C) shows no antibody staining of injured carotid tissue from an IL-1ß KO mouse.


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