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Home Antibody All anti-ABCB6 antibodies

Anti-ABCB6 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319439
  • Rabbit polyclonal anti-ABCB6 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417131) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 440-455 of human ABCB6 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, dog Concentration1.0 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:40,000 - 1:130,000, WB: 1:1,000 - 1:5,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. ABCB6 (ATP-binding cassette sub-family B member 6, also known as mitochondrial precursor ABC transporter 3, Mt-ABC transporter 3, and ABC transporter umat) is a member of the superfamily of ATP-binding cassette (ABC) transporters.  ABCB6 is a membrane-associated protein that transports various molecules across the extra- and intra-cellular membranes.  ABC genes are divided into seven distinct subfamilies (ABC1, DR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily confer multi-drug resistance (MDR) to cancer cells and are also involved in antigen presentation. ABCB6 also likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

Reference Data

Target NameHomo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) (ABCB6)
Alternative NameABC; ABC14; DUH3; LAN; MCOPCB7; MTABC3; PRP; umat
Database LinkNP_005680
Entrez Gene 10058 Human
Entrez Gene 478914 Dog
Function
Related PathwayTransmembraneDruggable Genome ABC transporters

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using affinity purified anti-ABCB6 antibody (right panel, lane B6) shows detection of Flag tagged human ABCB6 protein at 104 kDa and a truncated form of the protein at 79 kDa (arrowheads). The antibody successfully detected ABCB6 in KB cells transfected with the ABCB6 protein. A lysate prepared from KB cells without a vector insert (CV lane) should no reactivity with the antibody. The left panel shows a similar staining pattern using an anti-Flag™ antibody as a positive control. The membrane was probed with the primary antibody diluted to 1:1,400. Personal Communication, Jill Paterson, CCR-NCI, Bethesda, MD.

 

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