Home Antibody All anti-ABCB6 antibodies
Also for ABCB6 (NM_005689)
|This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 440-455 of human ABCB6 protein.|
||ELISA: 1:40,000 - 1:130,000, WB: 1:1,000 - 1:5,000
|0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2|
|This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. ABCB6 (ATP-binding cassette sub-family B member 6, also known as mitochondrial precursor ABC transporter 3, Mt-ABC transporter 3, and ABC transporter umat) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCB6 is a membrane-associated protein that transports various molecules across the extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, DR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily confer multi-drug resistance (MDR) to cancer cells and are also involved in antigen presentation. ABCB6 also likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
|Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 6 (ABCB6)|
|ABC; ABC14; DUH3; LAN; MCOPCB7; MTABC3; PRP; umat|
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Western blot using affinity purified anti-ABCB6 antibody (right panel, lane B6) shows detection of Flag tagged human ABCB6 protein at 104 kDa and a truncated form of the protein at 79 kDa (arrowheads). The antibody successfully detected ABCB6 in KB cells transfected with the ABCB6 protein. A lysate prepared from KB cells without a vector insert (CV lane) should no reactivity with the antibody. The left panel shows a similar staining pattern using an anti-Flag™ antibody as a positive control. The membrane was probed with the primary antibody diluted to 1:1,400. Personal Communication, Jill Paterson, CCR-NCI, Bethesda, MD.