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Home Antibody All anti-DCLRE1C antibodies

Anti-DCLRE1C Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319208 Goat polyclonal anti-Artemis antibody 100ug $325 3-7 Days
LC402945 DCLRE1C HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)
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Also for DCLRE1C (NM_001033855)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Request Antibody

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 482-495 of Human ARTEMIS (DCLRE1C DNA cross-link repair 1C).
Clone Name Isotype
Species Reactivityhuman Concentration1.2 mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:10,000 - 1:20,000, WB: 1:500 - 1:2,000, IHC: 1:1,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note Artemis has a role in T and B lymphocyte immunodeficiency and in predisposition to lymphoma through the NHEJ pathway of DNA repair. DNA-PKcs regulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5' and 3' overhang processing in non-homologous DNA end joining.

Reference Data

Target NameHomo sapiens DNA cross-link repair 1C (DCLRE1C), transcript variant a
Alternative NameA-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C
Database LinkNP_001029027
Entrez Gene 64421 Human
Function
Related PathwayDruggable Genome Non-homologous end-joiningPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blotting. Goat-anti-Artemis was used at a 1:500 dilution to detect Artemis is various cell lysates by Western blot. CJ is an Artemis deficient cell line and so no band is visible.
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Affinity Purified anti-Artemis antibody was used at a 1:1000 dilution to detect Artemis by immunohistochemistry in human spleen. Positive staining of T cells and B lymphocytes is observed in thymus, lymph nodes and spleen. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Alan Yen, LifeSpanBiosciences, Seattle, WA.
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