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Home Antibody All anti-CHUK antibodies

Anti-CHUK Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319147 Rabbit polyclonal IKK alpha antibody 100ul $325 3-7 Days
LC400513 CHUK HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenIKK a peptide corresponding to the highly conserved C-terminus region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat Concentration80 mg/mL
Guaranteed Application *IHC Suggested DilutionsELISA: 1:5,000 - 1:25,000, WB: 1:500 - 1:3,000
Note NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death.  In the cytoplasm NFkB is negatively modulated by the inhibitory proteins IkB.  In turn IkB is phosphorylated by a cellular kinase complex called IKK.  IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate IkB leading to its degradation and the resulting translocation of NFkB to the nucleus.  IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF- a, endotoxins and overexpression of cellular kinases like MEKK1.  Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.

Reference Data

Target NameHomo sapiens conserved helix-loop-helix ubiquitous kinase (CHUK)
Alternative NameIKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
Database LinkNP_001269
Entrez Gene 1147 Human
Entrez Gene 12675 Mouse
Entrez Gene 309361 Rat
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayChemokine signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Anti-IKKa antibody was diluted 1:500 to detect IKKa in human kidney tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.


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