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Home Antibody All anti-THRB antibodies

Anti-THRB Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319140 Rabbit polyclonal Thyroid Hormone Receptor beta 1 antibody 100ug $356 3-7 Days
LC400163 THRB HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenAnti-TR ß1 antibody is affinity purified from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human THRB isoform 1 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat Concentration1.0 mg/mL
Guaranteed Application *WB, IF Suggested DilutionsELISA: 1:20,000 – 1:200,000, WB: 1:500 - 1:2,000, IP: 1:100
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Tranduction research.

Reference Data

Target Namethyroid hormone receptor beta
Database LinkNP_000452
Entrez Gene 7068 Human
Entrez Gene 21834 Mouse
Entrez Gene 24831 Rat
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome Neuroactive ligand-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using affinity purified anti-THRB1 antibody shows detection of in vitro translated THRB1 (lane 2) and human thyroid stable cell line expressing THTRb1 (lane 3). No staining is evident in non transfected human thyroid cells (lane 1), over expressed THRA (lane 4) or HeLa stable cell line expressing THRA1 (lane 5). The band at ~62 kDa, indicated by the arrowheads, corresponds to THRB. Personal communication, H. Ying, NCI, Bethesda, MD

IF Image
IF anti -THRB1 (Thyroid hormone receptor Beta 1) antibody TA319140 Tissue: Mouse Dendritic cells Primary antibody: Anti THRB1 1:100 1 hr PBS 3% BSA (left) Normal rabbit IgG isotype control (right) Secondary Ab: 488 dye conjugate 1:1000 1 hr.


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