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Anti-THRB1 Antibody


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SKU Description Amount Price Availability*  
  • Rabbit polyclonal Thyroid Hormone Receptor beta 1 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400163) , 20ug Explanation
100ug 325 3-7 Days
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OriGene Data

ImmunogenAnti-TR ß1 antibody is affinity purified from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human THRB isoform 1 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat Concentration1.0 mg/mL
Guaranteed Application *WB, IF Suggested DilutionsELISA: 1:20,000 – 1:200,000, WB: 1:500 - 1:2,000, IP: 1:100
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Tranduction research.

Reference Data

Target NameHomo sapiens thyroid hormone receptor, beta (THRB), transcript variant 1
Database LinkNP_000452
Entrez Gene 7068 Human
Entrez Gene 21834 Mouse
Entrez Gene 24831 Rat
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome Neuroactive ligand-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using affinity purified anti-THRB1 antibody shows detection of in vitro translated THRB1 (lane 2) and human thyroid stable cell line expressing THTRb1 (lane 3). No staining is evident in non transfected human thyroid cells (lane 1), over expressed THRA (lane 4) or HeLa stable cell line expressing THRA1 (lane 5). The band at ~62 kDa, indicated by the arrowheads, corresponds to THRB. Personal communication, H. Ying, NCI, Bethesda, MD
IF Image
Immunofluorescence microscopy anti -THRB1 (Thyroid hormone receptor Beta 1) antibody TA319140 Tissue: Mouse Dendritic cells Primary antibody: Anti THRB1 1:100 1 hr PBS 3% BSA (left) Normal rabbit IgG isotype control (right) Secondary Ab: 488 dye conjugate 1:1000 1 hr Mounting: Fluoromount-G (Southern Biotechnology Associates, Birmingham, AL) for examination. This image appeared originally in Mascanfroni, Ivan D ; del Mar Montesinos M; Alamino Vanina A. ; Susperreguy S, Nicola JP, Ilarregui JM, Masini-Repiso AM, Rabinovich GA, Pellizas CG (2010) Nuclear Factor (NF)-kappa B-dependent Thyroid Hormone Receptor beta(1) Expression Controls Dendritic Cell Function via Akt Signaling. Journal of Biological Chemistry 285 (13), 9569-9582. DOI: 10.1074/jbc.M109.071241 Published: MAR 26 2010. Copyright © 2010, by the American Society for Biochemistry and Molecular Biology


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